1050 Arastradero Project Overview

History:

The School of Medicine recently entered into a sublease agreement for the two buildings located at 1050 Arastradero Road in the Stanford Research Park. These buildings allow the School of Medicine to provide contemporary research space for programs that cannot be accommodated on the campus due to severe space constraints. The 1050 Arastradero project will house the Stanford Institute for Stem Cell Biology and Regenerative Medicine (ISCBRM) and the Neurosciences Institute (NIS). The labs will predominantly house new recruits for the institutes.

The 1050 Arastradero project consists of two buildings totaling 75,045 gross square feet (gsf). The buildings were constructed in 1999 for the Shaklee Corporation. The School of Medicine is subleasing the property from Astellas Pharma Technologies Inc. and assumed the 15-year lease, effective January 1, 2005. The sublease provides the School of Medicine with an option to extend the sublease for an additional 8 years (to 2027), after the original term expires in 2019.

The School of Medicine will occupy the buildings in two phases. ISCBRM is scheduled to occupy a portion of Building 1 by the end of 2005. Phase 1 involves modifications to house the ISCBRM program, at a cost of $2.2 million, not requiring BoT authority. Phase 2, the subject of this Board action, involves renovations in the balance of Building 1, as well as Building 2.

Stanford's Institute for Cancer/Stem Cell Biology and Medicine was created in December 2002 as a multi-disciplinary initiative believed to be the first of its kind in the country. The institute’s mission is to bring together basic and clinical scientists in a unified effort to harness the power of stem cell biology and cancer biology to develop novel treatments for cancer as well as other devastating diseases such as diabetes, Parkinson’s disease and cardiovascular disease. The institute supports ongoing efforts at the medical school while attracting additional scientists who are internationally recognized in the fields of stem cell and cancer biology.

In 2005, to clarify the identity of two distinct yet overlapping areas of research, the institute split into two entities: The Stanford Institute for Stem Cell Biology and Regenerative Medicine and the Stanford Comprehensive Cancer Center.
The Neurosciences Institute at Stanford was established in 2003. NIS, along with the ISCBRM, represent two of the four institutes that are the focus of the School’s strategic plan. (The other two institutes are Cardiovascular Disease and Immunology, Transplantation and Infection.)

NIS was created to take a “big picture” approach to the neurosciences by integrating diverse disciplines in order to provide a more comprehensive view of the nervous system mechanisms and how the brain operates, changes, and breaks down. The mission of the Neurosciences Institute is to build a robust culture of innovation and interdisciplinary collaborations that provide the new resources and tools needed to understand and integrate across all levels of the nervous system. The NIS seeks an integrated understanding of the most fundamental aspects of nervous system structure and function during development, maturity, aging and disease.

Scope:

The 1050 Arastradero site has two 2-story buildings containing 75,045 gsf. The buildings were originally designed for pharmaceutical R&D and manufacturing, and incorporated a viewing corridor for touring prospective clients, partners and investors.

The Institute of Stem Cell Biology and Regenerative Medicine will be the primary occupant of Building 1, along with shared common facilities such as library, conference and break rooms. The Neurosciences Institute at Stanford will occupy the majority of Building 2, along with a vivarium that will support both institutes. Where possible the existing research and development (R&D) labs and finishes are being retained and reused. Further opportunities for shared support spaces are being investigated to maximize the usable area for research.

Phase 1 (Building 1), non-Board level project

Upon the completion of Phase 1, currently under construction, ISCBRM will move their research programs to existing labs on the 1st floor of Building 1. Support spaces will include rooms for tissue culture, florescence-activated cell sorter (FACs), microscopy, and cryogenics, and a small animal holding facility. The human embryonic stem cell program (hESC) will use general labs and two existing clean rooms. Existing conference rooms on level 2 will be available.

Phase 2 (Buildings 1 & 2)

In Phase 2, approximately 60,000 gsf of space will be renovated. The renovations will address the remainder of Building 1 (1st and 2nd floors) as well as Building 2.

The renovations in Building 1 will include three new laboratories, lab support rooms and upgraded conference room facilities. Approximately 600 gsf will be gained by infilling the existing observation area on the second floor of Building 2.

In Building 2, NIS will move their research programs into existing labs that will be renovated as well as several new laboratories located on both floors of the building. Laboratory support spaces will include microscopy, FACs rooms and tissue culture labs. A new shared animal facility will also be located on the 1st floor.
The laboratories in both buildings will require additional mechanical and electrical capacity. Additional emergency power must be provided as well.

Researchers from both buildings will share many of the public spaces, including the library, reception area, seminar, conference room, and lunchroom facilities in Building 1.